Host manipulation by cancer cells: Expectations, facts, and therapeutic implications.
Identifieur interne : 001D57 ( Main/Exploration ); précédent : 001D56; suivant : 001D58Host manipulation by cancer cells: Expectations, facts, and therapeutic implications.
Auteurs : Tazzio Tissot [France] ; Audrey Arnal [France] ; Camille Jacqueline [France] ; Robert Poulin [Nouvelle-Zélande] ; Thierry Lefèvre [France] ; Frédéric Mery [France] ; François Renaud [France] ; Benjamin Roche [France] ; François Massol [France] ; Michel Salzet [France] ; Paul Ewald [États-Unis] ; Aurélie Tasiemski [France] ; Beata Ujvari [Australie] ; Frédéric Thomas [France]Source :
- BioEssays : news and reviews in molecular, cellular and developmental biology [ 1521-1878 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Carcinogenèse, Tumeurs.
- immunologie : Carcinogenèse, Tumeurs.
- Animaux, Humains, Interactions hôte-parasite, Microenvironnement tumoral, Phénotype, Prolifération cellulaire, Tumeurs, Échappement de la tumeur à la surveillance immunitaire.
English descriptors
- KwdEn :
- MESH :
- immunology : Carcinogenesis, Neoplasms.
- pathology : Carcinogenesis, Neoplasms.
- therapy : Neoplasms.
- Animals, Cell Proliferation, Host-Parasite Interactions, Humans, Phenotype, Tumor Escape, Tumor Microenvironment.
Abstract
Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research.
DOI: 10.1002/bies.201500163
PubMed: 26849295
Affiliations:
- Australie, France, Nouvelle-Zélande, États-Unis
- Hauts-de-France, Kentucky, Languedoc-Roussillon, Nord-Pas-de-Calais, Occitanie (région administrative), Île-de-France
- Gif-sur-Yvette, Lille, Montpellier
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Le document en format XML
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France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Massol, Francois" sort="Massol, Francois" uniqKey="Massol F" first="François" last="Massol">François Massol</name><affiliation wicri:level="3"><nlm:affiliation>Université de Lille, UMR 8198, Unité EEP, Ecoimmunology Group, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lille, UMR 8198, Unité EEP, Ecoimmunology Group, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Salzet, Michel" sort="Salzet, Michel" uniqKey="Salzet M" first="Michel" last="Salzet">Michel Salzet</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM) INSERM U1192, Université Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Protéomique, Réponse Inflammatoire et 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UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Arnal, Audrey" sort="Arnal, Audrey" uniqKey="Arnal A" first="Audrey" last="Arnal">Audrey Arnal</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Jacqueline, Camille" sort="Jacqueline, Camille" uniqKey="Jacqueline C" first="Camille" last="Jacqueline">Camille Jacqueline</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Poulin, Robert" sort="Poulin, Robert" uniqKey="Poulin R" first="Robert" last="Poulin">Robert Poulin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, University of Otago, Dunedin, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>Department of Zoology, University of Otago, Dunedin</wicri:regionArea><wicri:noRegion>Dunedin</wicri:noRegion></affiliation></author><author><name sortKey="Lefevre, Thierry" sort="Lefevre, Thierry" uniqKey="Lefevre T" first="Thierry" last="Lefèvre">Thierry Lefèvre</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Mery, Frederic" sort="Mery, Frederic" uniqKey="Mery F" first="Frédéric" last="Mery">Frédéric Mery</name><affiliation wicri:level="3"><nlm:affiliation>Evolution, Génomes, Comportement and Ecologie, CNRS, IRD, University of Paris-Sud, Université Paris Saclay, Gif-sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Evolution, Génomes, Comportement and Ecologie, CNRS, IRD, University of Paris-Sud, Université Paris Saclay, Gif-sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Massol, Francois" sort="Massol, Francois" uniqKey="Massol F" first="François" last="Massol">François Massol</name><affiliation wicri:level="3"><nlm:affiliation>Université de Lille, UMR 8198, Unité EEP, Ecoimmunology Group, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lille, UMR 8198, Unité EEP, Ecoimmunology Group, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Salzet, Michel" sort="Salzet, Michel" uniqKey="Salzet M" first="Michel" last="Salzet">Michel Salzet</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM) INSERM U1192, Université Lille, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM) INSERM U1192, Université Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ewald, Paul" sort="Ewald, Paul" uniqKey="Ewald P" first="Paul" last="Ewald">Paul Ewald</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biology and the Program on Disease Evolution, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology and the Program on Disease Evolution, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Tasiemski, Aurelie" sort="Tasiemski, Aurelie" uniqKey="Tasiemski A" first="Aurélie" last="Tasiemski">Aurélie Tasiemski</name><affiliation wicri:level="3"><nlm:affiliation>Université de Lille, UMR 8198, Unité EEP, Ecoimmunology Group, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université de Lille, UMR 8198, Unité EEP, Ecoimmunology Group, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name><affiliation wicri:level="3"><nlm:affiliation>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CREEC/MIVEGEC, UMR IRD/CNRS/UM 5290, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author></analytic><series><title level="j">BioEssays : news and reviews in molecular, cellular and developmental biology</title><idno type="eISSN">1521-1878</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carcinogenesis (immunology)</term><term>Carcinogenesis (pathology)</term><term>Cell Proliferation</term><term>Host-Parasite Interactions</term><term>Humans</term><term>Neoplasms (immunology)</term><term>Neoplasms (pathology)</term><term>Neoplasms (therapy)</term><term>Phenotype</term><term>Tumor Escape</term><term>Tumor Microenvironment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Carcinogenèse (anatomopathologie)</term><term>Carcinogenèse (immunologie)</term><term>Humains</term><term>Interactions hôte-parasite</term><term>Microenvironnement tumoral</term><term>Phénotype</term><term>Prolifération cellulaire</term><term>Tumeurs ()</term><term>Tumeurs (anatomopathologie)</term><term>Tumeurs (immunologie)</term><term>Échappement de la tumeur à la surveillance immunitaire</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinogenèse</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Carcinogenèse</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carcinogenesis</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinogenesis</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Host-Parasite Interactions</term><term>Humans</term><term>Phenotype</term><term>Tumor Escape</term><term>Tumor Microenvironment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Interactions hôte-parasite</term><term>Microenvironnement tumoral</term><term>Phénotype</term><term>Prolifération cellulaire</term><term>Tumeurs</term><term>Échappement de la tumeur à la surveillance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Nouvelle-Zélande</li><li>États-Unis</li></country><region><li>Hauts-de-France</li><li>Kentucky</li><li>Languedoc-Roussillon</li><li>Nord-Pas-de-Calais</li><li>Occitanie (région administrative)</li><li>Île-de-France</li></region><settlement><li>Gif-sur-Yvette</li><li>Lille</li><li>Montpellier</li></settlement></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Tissot, Tazzio" sort="Tissot, Tazzio" uniqKey="Tissot T" first="Tazzio" last="Tissot">Tazzio Tissot</name></region><name sortKey="Arnal, Audrey" sort="Arnal, Audrey" uniqKey="Arnal A" first="Audrey" last="Arnal">Audrey Arnal</name><name sortKey="Jacqueline, Camille" sort="Jacqueline, Camille" uniqKey="Jacqueline C" first="Camille" last="Jacqueline">Camille Jacqueline</name><name sortKey="Lefevre, Thierry" sort="Lefevre, Thierry" uniqKey="Lefevre T" first="Thierry" last="Lefèvre">Thierry Lefèvre</name><name sortKey="Massol, Francois" sort="Massol, Francois" uniqKey="Massol F" first="François" last="Massol">François Massol</name><name sortKey="Mery, Frederic" sort="Mery, Frederic" uniqKey="Mery F" first="Frédéric" last="Mery">Frédéric Mery</name><name sortKey="Renaud, Francois" sort="Renaud, Francois" uniqKey="Renaud F" first="François" last="Renaud">François Renaud</name><name sortKey="Roche, Benjamin" sort="Roche, Benjamin" uniqKey="Roche B" first="Benjamin" last="Roche">Benjamin Roche</name><name sortKey="Salzet, Michel" sort="Salzet, Michel" uniqKey="Salzet M" first="Michel" last="Salzet">Michel Salzet</name><name sortKey="Tasiemski, Aurelie" sort="Tasiemski, Aurelie" uniqKey="Tasiemski A" first="Aurélie" last="Tasiemski">Aurélie Tasiemski</name><name sortKey="Thomas, Frederic" sort="Thomas, Frederic" uniqKey="Thomas F" first="Frédéric" last="Thomas">Frédéric Thomas</name></country><country name="Nouvelle-Zélande"><noRegion><name sortKey="Poulin, Robert" sort="Poulin, Robert" uniqKey="Poulin R" first="Robert" last="Poulin">Robert Poulin</name></noRegion></country><country name="États-Unis"><region name="Kentucky"><name sortKey="Ewald, Paul" sort="Ewald, Paul" uniqKey="Ewald P" first="Paul" last="Ewald">Paul Ewald</name></region></country><country name="Australie"><noRegion><name sortKey="Ujvari, Beata" sort="Ujvari, Beata" uniqKey="Ujvari B" first="Beata" last="Ujvari">Beata Ujvari</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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